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Revealing the Photophysical and Photochemical Reaction Processes of Carprofen in Different Solutions via Ultrafast Femtosecond to Nanosecond Transient Absorption

JOURNAL ARTICLE published 17 January 2022 in Chemical Research in Toxicology

Research funded by Li Ka Shing Foundation (2020LKSFG05A) | Department of Education of Guangdong Province (2019KCXTD007,2019KZDXM047,2021LSYS009) | National Natural Science Foundation of China (21773151)

Authors: Jiaxing He | Mingyue Liu | Lingfeng Yin | Ziqi Deng | Junhong Pang | Haoxian He | Li Dang | Ming-De Li

The Effect of Historical Data-Based Informative Prior on Benchmark Dose Estimation of Toxicogenomics

JOURNAL ARTICLE published 21 August 2023 in Chemical Research in Toxicology

Research funded by National Institute of Environmental Health Sciences (R42ES032642)

Authors: Chao Ji | Kan Shao

Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC–MS-Based Metabolomic Approaches

JOURNAL ARTICLE published 21 August 2023 in Chemical Research in Toxicology

Research funded by National Institute of Diabetes and Digestive and Kidney Diseases (R01DK121970) | Bill and Melinda Gates Foundation (INV-001902) | Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD087157,R01HD110038,R61/R33HD099995)

Authors: Xuan Qin | Yong Wang | Kevin R. MacKenzie | John M. Hakenjos | Si Chen | Saleh M. Khalil | Sung Yun Jung | Damian W. Young | Lei Guo | Feng Li

Identification of metabolites of 3,4-(methylenedioxy)methamphetamine in human urine

JOURNAL ARTICLE published May 1989 in Chemical Research in Toxicology

Authors: H. K. Lim | R. L. Foltz

Inhibition of 2,5-Hexanedione-Induced Protein Crosslinking by Biological Thiols: Chemical Mechanisms and Toxicological Implications

JOURNAL ARTICLE published July 1995 in Chemical Research in Toxicology

Authors: Mingshe Zhu | David C. Spink | Bin Yan | Shelton Bank | Anthony P. DeCaprio

Synthesis and Photocyclization of .alpha.-Methylene-.gamma.-butyrolactone-Thymine Heterodimers

JOURNAL ARTICLE published January 1995 in Chemical Research in Toxicology

Authors: Elena Gimenez-Arnau | Stephane Mabic | Jean-Pierre Lepoittevin

Metabolism of the nephrotoxin dichloroacetylene by glutathione conjugation

JOURNAL ARTICLE published January 1989 in Chemical Research in Toxicology

Authors: Wolfgang Kanhai | Wolfgang Dekant | Dietrich Henschler

Characterization of urinary metabolites from [1,2,methoxy-13C]-2-methoxyethanol in mice using carbon-13 nuclear magnetic resonance spectroscopy

JOURNAL ARTICLE published July 1992 in Chemical Research in Toxicology

Authors: Susan C. J. Sumner | Donald B. Stedman | David O. Clarke | Frank Welsch | Timothy R. Fennell

Chemical, physical, and toxicological characterization of fumes produced by heating tetrafluoroethene homopolymer and its copolymers with hexafluoropropene and perfluoro (propyl vinyl ether)

JOURNAL ARTICLE published March 1991 in Chemical Research in Toxicology

Authors: William C. Seidel | Kirby V. Scherer | Dwain Cline | Allan H. Olson | JoAnne K. Bonesteel | Daniel F. Church | Shamala Nuggehalli | William A. Pryor

Electrochemical Oxidation of Troglitazone: Identification and Characterization of the Major Reactive Metabolite in Liver Microsomes

JOURNAL ARTICLE published 20 October 2008 in Chemical Research in Toxicology

Authors: Kim G. Madsen | Gunnar Grönberg | Christian Skonberg | Ulrik Jurva | Steen H. Hansen | Jørgen Olsen

Development of a Battery of In Silico Prediction Tools for Drug-Induced Liver Injury from the Vantage Point of Translational Safety Assessment

JOURNAL ARTICLE published 15 February 2021 in Chemical Research in Toxicology

Research funded by Horizon 2020 Framework Programme (777365) | European Federation of Pharmaceutical Industries and Associations (777365)

Authors: James Rathman | Chihae Yang | J. Vinicius Ribeiro | Aleksandra Mostrag | Shraddha Thakkar | Weida Tong | Bryan Hobocienski | Oliver Sacher | Tomasz Magdziarz | Bruno Bienfait

Announcements and Meeting Calendar

JOURNAL ARTICLE published November 1992 in Chemical Research in Toxicology

Stereochemistry of the Biotransformation of 1-Hexene and 2-Methyl-1-hexene with Rat Liver Microsomes and Purified P450s of Rats and Humans

JOURNAL ARTICLE published 1 December 1998 in Chemical Research in Toxicology

Authors: Cinzia Chiappe | Antonietta De Rubertis | Giada Amato | Pier Giovanni Gervasi

Skin Sensitization to Linalyl Hydroperoxide:  Support for Radical Intermediates

JOURNAL ARTICLE published 1 September 1997 in Chemical Research in Toxicology

Authors: Michael Bezard | Ann-Therese Karlberg | Johan Montelius | Jean-Pierre Lepoittevin

Procainamide, a Drug Causing Lupus, Induces Prostaglandin H Synthase-2 and Formation of T Cell-Sensitizing Drug Metabolites in Mouse Macrophages

JOURNAL ARTICLE published 1 June 1999 in Chemical Research in Toxicology

Authors: Carsten Goebel | Christoph Vogel | Marty Wulferink | Stephanie Mittmann | Bernhardt Sachs | Sabine Schraa | Josef Abel | Gisela Degen | Jack Uetrecht | Ernst Gleichmann

The Presence of Lead Decreases the Availability ofmeso-2,3-Dimercaptosuccinic Acid for Analysis in the Monobromobimane Assay

JOURNAL ARTICLE published 1 November 1999 in Chemical Research in Toxicology

Authors: Susan Z. Lever | Teresa L. Parsons

Analysis of Acrolein-Derived 1,N2-Propanodeoxyguanosine Adducts in Human Leukocyte DNA from Smokers and Nonsmokers

JOURNAL ARTICLE published 14 January 2011 in Chemical Research in Toxicology

Authors: Siyi Zhang | Silvia Balbo | Mingyao Wang | Stephen S. Hecht

Synthesis of anti-7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydro-11-methylbenzo[a]pyrene and Its Reaction with DNA

JOURNAL ARTICLE published 1 April 1999 in Chemical Research in Toxicology

Authors: Jyh-Ming Lin | Dhimant Desai | Lehua Chung | Stephen S. Hecht | Shantu Amin

1,2,5,6-Diepoxyhexane and 1,2,7,8-Diepoxyoctane Cross-Link Duplex DNA at 5‘-GNC Sequences

JOURNAL ARTICLE published 1 January 1996 in Chemical Research in Toxicology

Authors: Michael J. Yunes | Sara E. Charnecki | Jennifer J. Marden | Julie T. Millard

Endothall thioanhydride: structural aspects of unusually high mouse toxicity and specific binding site in liver

JOURNAL ARTICLE published July 1990 in Chemical Research in Toxicology

Authors: Norihiro Kawamura | Yue Ming Li | Judith L. Engel | William G. Dauben | John E. Casida